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EVIDENCE OF AMYLOID ON FLORBETABEN-PET IS ASSOCIATED WITH REDUCED EPISODIC MEMORY 10 YEARS PRIOR: RESULTS FROM THE WOMEN’S HEALTHY AGEING PROJECT

      Background: Positron emission tomography (PET) has shown that accumulation of brain amyloid begins 20-30 years prior to AD dementia. It is less clear when decline in cognitive function begins. We sought to identify whether reduced episodic memory (EM) was present a decade earlier in participants of the Women's Healthy Ageing Project (WHAP) who showed evidence of amyloid accumulation on a recent amyloid PET scan.
      Methods: 92 participants with cognitive measures at 1999, 2002, 2004 and 2012-13 and 18F-Florbetaben PET (FBB-PET) imaging in 2012-13 were studied. All participants had normal range cognition at the 1999-2004 time points. FBB Standardised Uptake Value Ratio (SUVR) was calculated for the neocortical regions normalized to cerebellar cortex. Cognitive assessment included the CERAD word list recall (1999, 2002 and 2004) and CVLT-delay (2002, 2004 and 2012-13). EM scores were compared between tertile of FBB SUVR using ANOVA, and linear regression to adjust for age, education and E4 status.
      Results: No results submitted.
      Conclusions: Individuals with higher amounts of AD-pathology in later life demonstrate subtle decrements in episodic memory function up to ten years earlier.