It is important to know whether a mild cognitive impairment (MCI) patient has significant amyloid deposition to characterize the brain condition and predict the prognosis. We tried to compare the ability of various clinical, neuropsychological, structural imaging information, and their combinations for the discrimination of amyloid deposition positivity in the brain of MCI individuals.
Thirty amnestic MCI subjects were included. All the subjects underwent standardized clinical evaluation and neuropsychological tests including the Subjective Memory Complaints Questionnaire(SMCQ), Seoul Informant Report Questionnaire for Dementia(SIRQD), Clinical Dementia Rating(CDR), CERAD neuropsychological battery, stroop test as well as Apolipoprotein E(APOE) allele typing, MRI, and Pittsburgh compound B PET(Pib PET). PiB PET Images were classified as amyloid deposition positive if the mean 11C-PiB retention value was over 1.4 in one of the following regions: the frontal, lateral temporal, lateral parietal, precuneus/posterior cingulate cortices. In MRI, we measured mean gray matter(GM) thickness using freesurfer.
Among 30 subjects, 18 subjects classified as amyloid deposition positive group(MCI+). Compared to amyloid deposition negative(MCI-) group, MCI+ group showed significantly higher APOE e4 allele frequency, lower word list recall, higher stroop color-word test scores and lower mean cortical thickness in MRI. When amyloid deposition positivity prediction models based on logistic regression analyses were compared, the combined model of CERAD word list recall, stroop color word test, and MRI mean cortical thickness was the best discrimination model after adjusting age, education, and APOE e4 allele frequency(the prediction accuracy 90 %).
Our results suggest that the combination of verbal delayed recall, stroop color-word test, and cortical thickness on MRI may be useful for the discrimination of amyloid deposition status.
© 2016 Published by Elsevier Inc.