Advertisement

CONTROVERSY DEBATE: SINGLE BRAIN NETWORK DISORDER

      Background

      In Alzheimer’s disease, both rise and propagation of neurodegenerative changes are linked with macroscopic brain networks. The default mode network, which comprises midline structures of temporal, parietal, and prefrontal lobes, is of special interest, as suggested as the primary target of AD.

      Methods

      Review of previous findings from human multi-modal imaging and animal research.

      Results

      Brain changes of several dimensions and modalities, partly interrelated, affect primarly the default mode network.

      Conclusions

      The talk presents and discusses main findings and problems for the view that AD is a default mode network disorder.