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CHARACTERISTIC BRAIN VOLUMETRIC CHANGES IN THE AD PRECLINICAL SIGNATURE

      In the last decade, magnetic resonance imaging has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that conform what has been established as the AD signature. To which extent MRI can detect structural changes at the preclinical asymptomatic stage of AD -the preclinical AD signature- is still an area open for exploration.
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