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CEREBRAL MICROINFARCT INFLUENCES STRUCTURAL NETWORK TOPOLOGY IN ALZHEIMER’S DISEASE AND COGNITIVE IMPAIRMENT NO DEMENTIA

      Cerebral microinfarcts (CMI) have been commonly observed in Alzheimer’s Disease (AD) and associated with cognitive impairment (van Veluw et al., 2017). Previous animal studies demonstrated that CMI may impair white matter pathways and affect brain function that extends beyond lesion boundaries (Summers et al., 2017). Nevertheless, how CMI influences brain structural connectivity in living humans remains largely unknown. Hence, we for the first time aimed to investigate topological features of brain structural networks in relation to CMI presence. We hypothesized that patients with CMI would show disrupted structural network topology in higher-order cognitive networks (the default mode (DMN) and executive networks (ECN)) (Chong et al., 2017).
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