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Although tau-PET measurements are strongly linked to cognition, discrepancies in amyloid-PET
and tau-PET burden (“low tau”/“high amyloid” and “high tau/low amyloid” individuals)
have been recently reported in limited samples. Here we examined the frequency and
characteristics of these atypical tau-amyloid patterns and their relationship to cognitive
status across the spectrum of Alzheimer’s disease.
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