Advertisement

EXPLAINING [18F]-AV-1451 VARIABILITY IN HEALTHY CONTROLS ACROSS THE LIFESPAN

      Determining early tau accumulation is important for studying aging and AD, and is only as accurate as the signal to noise ratio of the tracer. Along with tau, [18F]-AV-1451 has been reported to bind to neuromelanin, MAO, iron, lepto-meningeal melanocytes, and microhemorrhages. [18F]-AV-1451 successfully differentiates healthy controls (HCs) from ADs, however we wanted to explore off-target binding and the variability seen in HCs expected to have no tau accumulation (Figure 1).
      To read this article in full you will need to make a payment
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'