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Neuroimaging characteristics in Alzheimer’s disease (AD) have been shown to differ
according to age, driven largely by late-onset patients that show focal medial temporal
with little cortical involvement. Other comorbidities are likely to contribute to
impairment in these late-onset patients. However, it is unclear whether age influences
neuroimaging characteristics in patients with atypical variants of AD who typically
present younger with predominant deficits in cognitive domains other than memory.
We aimed to assess the associations between age and regional tau uptake measured with
[18F]AV-1451 PET, atrophy measured on MRI and beta-amyloid uptake measured with Pittsburgh
Compound B (PiB) PET in atypical AD.
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