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THE INFLUENCE OF AGE ON REGIONAL [18F]AV-1451 PET, PITTSBURGH COMPOUND B PET AND MRI ATROPHY IN ATYPICAL ALZHEIMER’S DISEASE

      Neuroimaging characteristics in Alzheimer’s disease (AD) have been shown to differ according to age, driven largely by late-onset patients that show focal medial temporal with little cortical involvement. Other comorbidities are likely to contribute to impairment in these late-onset patients. However, it is unclear whether age influences neuroimaging characteristics in patients with atypical variants of AD who typically present younger with predominant deficits in cognitive domains other than memory. We aimed to assess the associations between age and regional tau uptake measured with [18F]AV-1451 PET, atrophy measured on MRI and beta-amyloid uptake measured with Pittsburgh Compound B (PiB) PET in atypical AD.
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