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Metabotropic glutamate subtype 5 receptors (mGluR5) play an important role in Alzheimer’s
disease (AD) by mediating the synaptotoxic action of amyloid-beta oligomers. mGluR5
receptors are present pre- and post-synaptically throughout the cortex and hippocampus
where they modulate synaptic transmission. We utilized the mGluR5 selective positron
emission tomography (PET) radioligand to investigate mGluR5 binding and hypothesized
reductions in the hippocampus and association cortical regions affected in AD.
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