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PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER’S DISEASE

      Metabotropic glutamate subtype 5 receptors (mGluR5) play an important role in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-beta oligomers. mGluR5 receptors are present pre- and post-synaptically throughout the cortex and hippocampus where they modulate synaptic transmission. We utilized the mGluR5 selective positron emission tomography (PET) radioligand to investigate mGluR5 binding and hypothesized reductions in the hippocampus and association cortical regions affected in AD.
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