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NEUROINFLAMMATION AND 18F-AV-1451 PET FINDINGS IN SEMANTIC DEMENTIA

      Semantic dementia (SD) is a progressive naming disorder with atrophy in the anterior portion of the left temporal lobe most often associated with longTAR DNA-binding protein (TDP)-43-positive neuropil threads and dystrophic neuritis (type C), and only rarely due to a primary tauopathy. However patients with SD show elevated uptake of the tau PET tracer 18F-AV-1451 in anterior temporal regions. This uptake could be related to non-specific binding, perhaps caused by inflammation, as SD is associated with a propensity for autoimmune disease and increased inflammation in peripheral blood. We studied whether there was an association between [18F]AV-1451 uptake and inflammation, measured with the TSPO tracer 11C-PBR28, in anterior temporal regions.
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