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DISTINCT LONGITUDINAL CORTICAL ATROPHY IN NON-AMNESTIC COMPARED TO AMNESTIC ALZHEIMER'S DISEASE SUGGESTS DIFFERENT PATTERNS OF SPREADING PATHOLOGY

      The typical progression of atrophy over time in amnestic Alzheimer's disease (aAD) is well known, starting from the medial temporal lobes (MTL) and subsequently involving the neocortex. Amnestic AD patients experience primary memory difficulty with later deficits in other cognitive domains. In contrast, non-amnestic AD (naAD) patients are characterized by initial impairments in non-memory domains. Cross-sectional studies in these phenotypes suggest accelerated neocortical atrophy coupled with minimal longitudinal change in the MTL, but longitudinal studies to corroborate these findings are rare.
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