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University of Milano-Bicocca, Milan, ItalySchool of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Milan, ItalyPenn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA
The typical progression of atrophy over time in amnestic Alzheimer's disease (aAD)
is well known, starting from the medial temporal lobes (MTL) and subsequently involving
the neocortex. Amnestic AD patients experience primary memory difficulty with later
deficits in other cognitive domains. In contrast, non-amnestic AD (naAD) patients
are characterized by initial impairments in non-memory domains. Cross-sectional studies
in these phenotypes suggest accelerated neocortical atrophy coupled with minimal longitudinal
change in the MTL, but longitudinal studies to corroborate these findings are rare.
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