Advertisement

ANTEMORTEM LONGITUDINAL MRI METRICS AS A BIOMARKER OF POSTMORTEM BRAAK NFT STAGING

      The diagnosis of Alzheimer’s disease (AD) can only be established through postmortem examination. The most widely used assessment method is "ABC staging", involving the neuropathological gradation of diffuse amyloid plaques, neurofibrillary tangles (NFT), and neuritic plaques. NFT pathology is the strongest correlate of atrophy on structural magnetic resonance imaging (MRI) amongst all AD pathological features. Conversely, our goal was to identify regional MRI metrics for which longitudinal trajectories were the strongest predictors of postmortem neurofibrillary degeneration.
      To read this article in full you will need to make a payment
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'