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LOSS OF GREY MATTER CONNECTIVITY IN THE PRECUNEUS IS ASSOCIATED WITH FASTER ATROPHY RATES IN PRECLINICAL ALZHEIMER’S DISEASE

      To advance preventive strategies it is important to develop measures that can predict future brain atrophy in early stage Alzheimer’s disease (AD). Loss of grey matter connectivity is related with amyloid burden in cognitively intact older subjects, and predictive for cognitive decline in preclinical AD [Tijms et al., 2018] We studied whether lower grey matter connectivity in brain areas that show the earliest accumulation of amyloid, medial prefrontal cortex and precuneus, can predict which brain areas will show faster atrophy rates in preclinical AD.
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