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To advance preventive strategies it is important to develop measures that can predict
future brain atrophy in early stage Alzheimer’s disease (AD). Loss of grey matter
connectivity is related with amyloid burden in cognitively intact older subjects,
and predictive for cognitive decline in preclinical AD [Tijms et al., 2018] We studied
whether lower grey matter connectivity in brain areas that show the earliest accumulation
of amyloid, medial prefrontal cortex and precuneus, can predict which brain areas
will show faster atrophy rates in preclinical AD.
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