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RELATIONSHIPS BETWEEN MEAN CORTICAL AMYLOID BURDEN AND REGIONAL GRAY MATTER REDUCTIONS IN ALZHEIMER’S DEMENTIA, MILD COGNITIVE IMPAIRMENT AND UNIMPAIRED OLDER ADULTS

      In this study, we used voxel-based morphometry (VBM) to characterize relationships between florbetapir PET measurements of mean cortical amyloid-β (Ab) burden and MRI measurements of regional gray matter volume in over a thousand persons from the AD Neuroimaging Initiative (ADNI), including those who met clinical criteria for dementia or mild cognitive impairment (MCI) due to AD and in cognitively unimpaired APOE4 carriers and non-carriers.
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