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ASSESSMENT OF EARLY AMYLOID PATHOLOGY USING [18F]FLUTEMETAMOL POSITRON EMISSION TOMOGRAPHY: COMPARING VISUAL READ, SEMI-QUANTITATIVE AND QUANTITATIVE METHODS

      Reliable in vivo identification of amyloid pathology in the cognitively normal elderly population is of utmost importance, considering the shift in research focus to this population. Visual interpretation of semi-quantitative standardized uptake value ratios (SUVR) images is thought to be sufficient for this purpose. However, SUVR can overestimate amyloid burden and shows lower inter-reader agreement compared to fully quantitative non-displaceable binding potentials (BPND) in a clinical population. We aimed to compare these measurements for the assessment of early amyloid pathology in an elderly control population.
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