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Reliable in vivo identification of amyloid pathology in the cognitively normal elderly
population is of utmost importance, considering the shift in research focus to this
population. Visual interpretation of semi-quantitative standardized uptake value ratios
(SUVR) images is thought to be sufficient for this purpose. However, SUVR can overestimate
amyloid burden and shows lower inter-reader agreement compared to fully quantitative
non-displaceable binding potentials (BPND) in a clinical population. We aimed to compare these measurements for the assessment
of early amyloid pathology in an elderly control population.
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