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COMPARING THE CENTILOID SCALE FOR PITTSBURGH COMPOUND B AND FLORBETAPIR IN LONGITUDINAL PET STUDIES OF SPORADIC AD

      Amyloid imaging with Positron Emission Tomography (PET) plays a critical role in research and clinical assessment of Alzheimer’s disease (AD). Radiopharmaceutical tracers, such as [11C]Pittsburgh Compound B (PiB) and [18F]florbetapir, were developed to provide in vivo quantitative estimates of amyloid in humans as an AD biomarker. However, differences in tracer properties and analysis methods produce significant variability in estimates of amyloid burden. To address this issue, the Centiloid Working Group recommended amyloid SUVRs be converted to a standardized scale called Centiloid1 for across tracer comparisons. We provide the first comparison of Centiloid values, without and with partial volume correction (PVC), for PiB and florbetapir in longitudinal PET studies of sporadic AD.
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