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Amyloid imaging with Positron Emission Tomography (PET) plays a critical role in research
and clinical assessment of Alzheimer’s disease (AD). Radiopharmaceutical tracers,
such as [11C]Pittsburgh Compound B (PiB) and [18F]florbetapir, were developed to provide in vivo quantitative estimates of amyloid
in humans as an AD biomarker. However, differences in tracer properties and analysis
methods produce significant variability in estimates of amyloid burden. To address
this issue, the Centiloid Working Group recommended amyloid SUVRs be converted to
a standardized scale called Centiloid1 for across tracer comparisons. We provide the first comparison of Centiloid values,
without and with partial volume correction (PVC), for PiB and florbetapir in longitudinal
PET studies of sporadic AD.
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