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COMPARING CEREBRAL WHITE MATTER, CEREBELLAR, AND PONTINE REFERENCE REGIONS TO CHARACTERIZE FLORBETAPIR PET MEASUREMENTS OF AMYLOID-β BURDEN IN PSEN1 E280A MUTATION CARRIERS AND NONCARRIERS FROM THE COLOMBIAN AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE KINDRED

      We previously demonstrated that a cerebral white matter reference region could improve the ability of longitudinal florbetapir standard uptake value (SUV) ratios (SUVR) to track changes in amyloid-β (Aβ) levels (Chen et al., 2015). Here we sought to compare white matter to two candidate reference regions to test their the ability to detect Aβ elevations and associations with age and memory decline with cross-sectional florbetapir SUVRs in Presenilin (PSEN1) E280A mutation carriers from the Colombian Autosomal Dominant Alzheimer’s Disease (ADAD) kindred.
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