Advertisement

CONFOCAL ANALYSIS OF FLUORESCENT SIGNAL DERIVED FROM CN-FLUTEMETAMOL LABELED DIFFUSE AND NEURITIC PLAQUES IN ALZHEIMER’S DISEASE

      Specificity and sensitivity of [18F]flutemetamol (Vizamyl) PET are high for detecting neuritic amyloid-beta plaques (NP). Some false-positive results from the Flutemetamol clinical-pathological study, and high [18F]flutemetamol retention in AD striatum, indicate this radiotracer detects both NP and diffuse plaques (DP). Flutemetamol fluorescent derivative CN-flutemetamol labels morphologically diverse plaque types, with the amyloid core of NP exhibiting the brightest fluorescence. The current histopathology study uses CN-flutemetamol to explore quantitatively flutemetamol fluorescence in both NP and DP.
      To read this article in full you will need to make a payment
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'