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ESTIMATION OF AMYLOID LOAD USING [18F]FLUTEMETAMOL AND A NORMALIZATION DERIVED WEIGHTING FACTOR: POTENTIAL APPLICATIONS IN AMYLOID PET

      Though the burden of brain amyloid-β (Aβ) is routinely estimated using mean cortical standardized uptake value ratio (SUVR) values derived from Aβ positron emission tomography (PET), increased sensitivity for the detection of Aβ burden has recently been shown using a novel outcome measure known as amyloid load (AβL). In order to generate AβL, an algorithm is applied in order to match canonical images derived from logistic growth modeling to a static PET image. In the present study, we aimed to investigate, using [18F]flutemetamol PET, whether a weighting factor (W) derived from an analogous principal component analysis (PCA) based normalization approach might provide an additional alternative to SUVR.
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