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VERBAL FLUENCY MEASURES ARE ASSOCIATED WITH ALZHEIMER’S DISEASE BIOMARKERS IN CLINICALLY UNIMPAIRED LATE MIDDLE-AGED ADULTS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER’S PREVENTION

      Prior research indicates that semantic fluency (SF) and phonemic fluency (PF) tasks are sensitive measures of cognitive decline in adults with mild cognitive impairment (MCI) and AD dementia. Most research on SF and PF in MCI and AD has examined total words generated, whereas some researchers suggest that clustering (producing words within sub-categories) and switching (shifting between sub-categories) may also be sensitive to MCI and AD. Furthermore, limited research has examined these additional measures of PF and SF in clinically unimpaired (CU) individuals with AD-related pathology (preclinical AD). We explored relationships between verbal fluency (total, clustering and switching), and AD biomarkers in late middle-aged CU adults.
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