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Prior research indicates that semantic fluency (SF) and phonemic fluency (PF) tasks
are sensitive measures of cognitive decline in adults with mild cognitive impairment
(MCI) and AD dementia. Most research on SF and PF in MCI and AD has examined total
words generated, whereas some researchers suggest that clustering (producing words
within sub-categories) and switching (shifting between sub-categories) may also be
sensitive to MCI and AD. Furthermore, limited research has examined these additional
measures of PF and SF in clinically unimpaired (CU) individuals with AD-related pathology
(preclinical AD). We explored relationships between verbal fluency (total, clustering
and switching), and AD biomarkers in late middle-aged CU adults.
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