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LONGITUDINAL ACCUMULATION OF β-AMYLOID ON PET IN DEMENTIA WITH LEWY BODIES AND RELATIONSHIP TO CLINICAL DISEASE PROGRESSION

      Patients with clinical probable dementia with Lewy bodies (DLB) commonly have β-amyloid pathology in addition to Lewy body disease. Understanding the influence of β-amyloid deposition on clinical disease progression in DLB is critical for prognosis and targeting underlying neurodegenerative pathologies. However, it has been shown that the rate of β-amyloid accumulation vs baseline SUVR follows an inverted U-shape among normal to clinical AD dementia subjects; but, the nature of this relationship is unknown in DLB. Our objective was to determine the rate of longitudinal β-amyloid accumulation by PET vs baseline SUVR in DLB compared to controls, and the association between β-amyloid accumulation and disease progression in DLB.
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