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MULTIVARIATE PATTERN ANALYSIS ON A LONGITUDINAL COHORT OF COGNITIVELY NORMAL ELDERLY REVEALS DISTINCT STAGES OF REGIONAL AMYLOID DEPOSITION

      Accumulation of cerebral beta-amyloid (Aβ) is a hallmark of Alzheimer’s Disease (AD). The widespread distribution of Aβ in late AD stages is well-established, however the regional progression of Aβ deposition in early AD remains uncertain. We studied regional Aβ deposition in cognitively normal (CN) individuals from the Baltimore Longitudinal Study of Aging using multivariate pattern analysis techniques and nonlinear mixed-effects (nLME) models.
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