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UNBIASED ASSESSMENT OF GLOBAL AMYLOID LOAD AS DETERMINED BY VOXEL-WISE RECEIVER OPERATING CHARACTERISTIC ANALYSIS

      Recent efforts have focused on characterizing individuals as amyloid positive or negative in order to enrich disease-modifying clinical trials. However, current Aβ dichotomizations ignore the regional distribution of amyloid pathology, which may have important implications for clinical progression. In this study, we investigated the regional patterns of amyloid deposition that can optimally differentiate between AD patients and controls.
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