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The Cascading Network Failure (CNF) model of Alzheimer’s disease (AD) posits an early
load-shift from tau-vulnerable systems (e.g. temporal memory systems) to the posterior
DMN (pDMN), followed by a shift from the pDMN to hubs of high connectivity, amyloid
accumulation and subsequent escalation of tau accumulation in the vulnerable system(s).
This implies an association between tau accumulation and pDMN connectivity before
amyloidosis, between amyloid and hubs of high connectivity and an interaction between
pDMN connectivity and hubs. We explored this by comparing the spatial patterns of
amyloid and tau accumulation, pDMN connectivity changes and relative hubness, measured
as relative degree centrality.
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