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VARIABILITY IN PDMN CONNECTIVITY AND RELATIVE HUBNESS IN COGNITIVELY NORMAL INDIVIDUALS PREDICT AMYLOID AND TAU DEPOSITION PATTERNS IN TYPICAL ALZHEIMER’S DISEASE

      The Cascading Network Failure (CNF) model of Alzheimer’s disease (AD) posits an early load-shift from tau-vulnerable systems (e.g. temporal memory systems) to the posterior DMN (pDMN), followed by a shift from the pDMN to hubs of high connectivity, amyloid accumulation and subsequent escalation of tau accumulation in the vulnerable system(s). This implies an association between tau accumulation and pDMN connectivity before amyloidosis, between amyloid and hubs of high connectivity and an interaction between pDMN connectivity and hubs. We explored this by comparing the spatial patterns of amyloid and tau accumulation, pDMN connectivity changes and relative hubness, measured as relative degree centrality.
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