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PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMER’S DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME-BASED SPREAD

      Neurodegeneration in Alzheimer’s Disease appears more closely related to regional deposition of tau than amyloid. What is unclear is how local and global tau combine to drive subsequent atrophy. Here we tested whether a network-based model of tau could improve our prediction of longitudinal gray matter atrophy based on a baseline Flortaucipir PET scan.
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