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CSF SPDGFRB, A MEASURE OF VASCULAR DYSFUNCTION, IS RELATED TO DISRUPTED FUNCTIONAL CONNECTIVITY AMONG BRAIN REGIONS ASSOCIATED WITH ALZHEIMER’S DISEASE

      Our understanding of large-scale changes in neural function associated with early stages of Alzheimer’s Disease (AD) has been expanded by employing rsfMRI and brain connectomics. AD pathophysiology has been associated with reduced communication and coordination among regions important for cognition. Recently, studies using rsfMRI in a brain connectomic framework have shown aberrant functional connectivity (FC) in the earliest stages of AD, concluding that abnormal FC may be one of the earliest indicators of neurodegeneration. Our aim was to examine FC between brain regions known to be affected in AD within an at-risk cohort via vascular impairment as measured by CSF soluble platelet-derived growth factor receptor b (sPDGFRb).
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