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Our understanding of large-scale changes in neural function associated with early
stages of Alzheimer’s Disease (AD) has been expanded by employing rsfMRI and brain
connectomics. AD pathophysiology has been associated with reduced communication and
coordination among regions important for cognition. Recently, studies using rsfMRI
in a brain connectomic framework have shown aberrant functional connectivity (FC)
in the earliest stages of AD, concluding that abnormal FC may be one of the earliest
indicators of neurodegeneration. Our aim was to examine FC between brain regions known
to be affected in AD within an at-risk cohort via vascular impairment as measured
by CSF soluble platelet-derived growth factor receptor b (sPDGFRb).
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