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The default mode network (DMN) is well-recognized as being involved in memory and
affected by dementia due to Alzheimer’s disease (AD), with differences in this network
previously noted between healthy controls and AD patients. Previous studies of DMN
effective connectivity in AD, such as used models of hemodynamic effective connectivity
along with t-tests to compare connections between groups. Dynamic causal modeling
(DCM) was used to explore neuronal effective connectivity differences between healthy
controls and a group of mild cognitive impairment (MCI) and AD patients.
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