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MOLECULAR ESTIMATION OF ALZHEIMER’S DISEASE PROGRESSION

      We infer disease progression for Alzheimer’s disease (AD) using RNA-Seq data from post-mortem brain samples from the Accelerating Medicine Partnership - Alzheimer’s Disease (AMP-AD) consortia with a machine learning method. We show that this estimate of disease progression is concordant with neuropathological and clinical measures of disease and we identify the genetic basis of disease progression.
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