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EFFECT OF LIPID METABOLISM ON RACIAL DISPARITIES IN ALZHEIMER’S DISEASE

      High prevalence of Alzheimer’s disease (AD) amongst African Americans (AAs) is less studied. Pathologically, primary hallmarks of AD (e.g. plaque formation or neurofibrillary tangles) are similar in AAs compared to non-Hispanic whites (NHWs). Comorbidities such as high cholesterol and hypertension are also more prevalent in AAs and can increase AD risk. Central to these comorbidities and AD is dysregulated lipid metabolism. Proteins with known function in lipid metabolism proteins constitute 3% of the human proteome, and can be measured to study alterations in these pathways. We performed a pilot proteomics analysis in plasma to study altered lipid metabolism in AAs and NHWs who were clinically diagnosed with AD or cognitively normal (CN) individuals. The results from this study and implications for racial disparities in AD will be presented.
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