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Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, NetherlandsInstitutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom
For the development of therapies measures are needed to monitor disease progression
in Alzheimer’s disease (AD). Grey matter connectivity is disrupted in AD, manifesting
already in preclinical stages due to aggregating amyloid, and is related to disease
progression in predementia AD. It remains unclear, how these disruptions evolve over
time and whether they translate to cognitive decline within individuals across the
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