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GREY MATTER CONNECTIVITY TRAJECTORIES ACROSS THE ALZHEIMER’S DISEASE CONTINUUM AND ASSOCIATIONS WITH COGNITIVE DECLINE

      For the development of therapies measures are needed to monitor disease progression in Alzheimer’s disease (AD). Grey matter connectivity is disrupted in AD, manifesting already in preclinical stages due to aggregating amyloid, and is related to disease progression in predementia AD. It remains unclear, how these disruptions evolve over time and whether they translate to cognitive decline within individuals across the disease continuum.
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