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MILD COGNITIVE IMPAIRMENT PROGRESSING TO DEMENTIA WITH LEWY BODIES: REGIONAL ATROPHY RATES AND RELATIONSHIP TO AV-1451 UPTAKE

      Patients with mild cognitive impairment (MCI) with visual hallucinations, REM-sleep behavior disorder, parkinsonism or fluctuations may have prodromal dementia with Lewy bodies (DLB), but they often have overlapping Alzheimer’s disease-related pathology as well. Identifying the imaging findings associated with prodromal DLB is necessary for understanding the disease progression and predicting who will progress to probable DLB in the near future. We investigated the distribution and magnitude of regional brain atrophy rates in prodromal DLB. Using AV-1451 PET, we assessed the association of tau-related pathology and atrophy rates.
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