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As intervention studies in Alzheimer’s disease (AD) move towards preclinical and prodromal
target populations, a major challenge has been finding sensitive outcome measures
to disease progression at these early stages. We hypothesize that longitudinal change
of the medial temporal lobe (MTL) subregions (the sites of earliest tangle pathology)
measured by a new and unique approach that accounts for the common confounds (Figure
1) are more sensitive to disease progression at early stages compared to longitudinal
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