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GENDER DIFFERENCES IN THE ASSOCIATION BETWEEN LONGITUDINAL BRAIN CHANGES AND BASELINE LEVELS OF CSF ALZHEIMER'S DISEASE AND GLIAL BIOMARKERS IN HEALTHY ELDERS

      The incidence of Alzheimer's disease (AD) doubles in women. Being age the major risk factor for AD, this difference was thought to be due to women’s longer lifespan. However, recent studies suggest that sexual hormones could have an impact on disease progression. The aim of this study is to assess whether there are gender differences in the association between baseline levels of CSF biomarkers for AD (Aβ42, ptau) and for glial activity (YKL40 and sTREM2) and longitudinal brain volume changes in cognitively unimpaired adults.
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