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UTILITY OF MRI IN DETECTION OF ATROPHY IN HIPPOCAMPAL SCLEROSIS OF AGING

      Hippocampal sclerosis of aging (HS) is a common neurodegenerative pathology and a strong predictor of dementia in older individuals. HS is characterized by disproportionate atrophy and gliosis of subiculum and CA1 region of hippocampus. HS is commonly misdiagnosed as Alzheimer’s disease (AD) as there are no established biomarkers for HS. Here we tested the hypothesis that those with HS at autopsy would have a distinct pattern of MRI-defined hippocampal subfield atrophy compared to those with and without AD neuropathology (ADNP).
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