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Hippocampal sclerosis of aging (HS) is a common neurodegenerative pathology and a
strong predictor of dementia in older individuals. HS is characterized by disproportionate
atrophy and gliosis of subiculum and CA1 region of hippocampus. HS is commonly misdiagnosed
as Alzheimer’s disease (AD) as there are no established biomarkers for HS. Here we
tested the hypothesis that those with HS at autopsy would have a distinct pattern
of MRI-defined hippocampal subfield atrophy compared to those with and without AD
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