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CROSS-SECTIONAL AND LONGITUDINAL MEDIAL TEMPORAL LOBE SUBREGIONAL ATROPHY IN SUSPECTED NON-ALZHEIMER’S PATHOPHYSIOLOGY

      Suspected non-Alzheimer’s pathophysiology (SNAP) individuals display Alzheimer’s disease (AD) like neurodegeneration in the absence of β–amyloid. While primary age-related tauopathy (PART) is thought to underlie neurodegeneration in SNAP, there is limited evidence to support this hypothesis. To potentially gain insight into the underlying pathology, we investigate medial temporal lobe (MTL) subregional atrophy patterns in cognitively normal SNAP individuals, as these subregions are thought to be differentially vulnerable to pathologies (e.g. tau, TDP-43).
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