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Trisomy of chromosome 21 in Down syndrome results in an overexpression of the gene
encoding amyloid precursor protein and an early presence of β-amyloid plaques in the
brain. [11C]PiB is a commonly used PET radiotracer for detecting the presence of β-amyloid plaques.
A novel outcome metric of global amyloid load (AβL) was developed to provide a quantitative index of the progression of this pathophysiology1. This study aims to implement and assess longitudinal AβL change in DS.
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