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SPATIAL ASSOCIATIONS OF Aβ WITH TAU DEPOSITION IN DOWN SYNDROME

      Down syndrome (DS) is frequently associated with the presence of comorbid beta-amyloid (Aβ) and neurofibrillary tau tangles, both of which are the signature hallmarks of Alzheimer’s disease (AD). Clarifying the coupling between both neuropathologies may provide further insights into the disease mechanisms and inform optimisation of clinical trials in DS. However, the in vivo relationships between Aβ and tau remains to be delineated in people with DS.
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