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SLEEP, COGNITION, AND β-AMYLOID IN ADULTS WITH DOWN SYNDROME

      In Down syndrome (DS), the overproduction of amyloid precursor protein gene results in increased β-amyloid accumulation and consequently, an increased risk for early Alzheimer’s disease (AD). Individuals with DS also have an increased prevalence of disordered sleep. Poor sleep has been associated with increased AD-related pathology and cognitive impairment in the general population; however, the relationship between β-amyloid accumulation, cognition and sleep in the DS population remains unknown.
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