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Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, GermanyUniversity of Cologne, Faculty of Medicine, Cologne, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Bonn/Cologne, Germany
KU Leuven and University Hospital Leuven, Leuven, BelgiumAlzheimer Research Centre, KU Leuven, Leuven, BelgiumNuclear Medicine and Molecular Imaging, KU Leuven, Leuven, BelgiumNuclear Medicine Department, UZ Leuven, Leuven, Belgium
Three fluorine-18-labelled tracers are currently commercially available to measure
cerebral amyloid pathology and assist in the diagnosis of Alzheimer’s Disease (AD);
Florbetapir, Flutemetamol and Florbetaben. FDA/EMA approved visual rating guidelines
to determine if a scan is positive or negative differ considerably in regards to suggested
color scale, intensity scaling, definitions of a region and signal thresholds to determine
positivity. Standardization of visual reading would be highly desirable to ensure
that diagnostic classification, patient selection and therapeutic decisions are comparable,
independently of the tracer and reader.
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