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LONGITUDINAL RATES OF AMYLOID ACCUMULATION IN A 70-YEAR OLD BRITISH BIRTH COHORT

      Characterising biomarker trajectories during the presymptomatic phase of Alzheimer’s disease is critical to identifying optimal windows for early treatment. Accumulation of β-amyloid plaques is an early change in the disease and can be assessed quantitatively in vivo using amyloid-specific PET tracers. These measures are a potential outcome measure for secondary prevention studies, but they can be affected by numerous factors, including age, genetics, vascular changes, and analysis technique. We examined longitudinal changes in amyloid accumulation in a large sample of healthy individuals from a British birth cohort.
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