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ANATOMICAL STAGING OF BETA-AMYLOID ACCUMULATION BASED ON LONGITUDINAL ASSESSMENT OF GLOBALLY PIB NEGATIVE ADULTS

  • Michelle E. Farrell
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
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  • Aaron P. Schultz
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
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  • Michael J. Properzi
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
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  • Heidi IL. Jacobs
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands
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  • Bernard J. Hanseeuw
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium
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  • Rachel F. Buckley
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    University of Melbourne, Melbourne, Australia

    The Florey Institute of Neuroscience and Mental Health, Parkville, Australia
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  • Reisa A. Sperling
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
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  • Keith A. Johnson
    Affiliations
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Department of Radiology, Division of Molecular Imaging and Nuclear Medicine, Massachusetts General Hospital, Boston, MA, USA

    Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, MA, USA
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      Anatomical staging of Aβ accumulation has thus far largely relied on cross-sectional PIB and autopsy data. The present study sought to instead derive anatomical staging from the spatiotemporal dynamics of Aβ using longitudinal PIB data. We examined initially global PIB- adults, to focus on identifying a subset of early-accumulating (Stage-1) regions which exhibit slight baseline regional elevations that predict subsequent global changes in Aβ, and later-accumulating (Stage-2) regions that were not predictive of change but were themselves changing. Regions not yet predictive of change nor changing in global PIB- adults were presumed to be latest-accumulating (Stage-3).
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